abstract：:Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been associated with various chronic diseases such as asthma and atherosclerosis, possibly because the pathogen can exist in a persistent form. C. pneumoniae persistently infect DCs in a TNF-alpha dependent manner. The present study investigated wh...

journal_title：Microbes and infection

authors： Njau F,Geffers R,Thalmann J,Haller H,Wagner AD

更新日期：2009-11-01 00:00:00

abstract：:Many viruses regulate a crucial point in the apoptotic pathway by expressing viral Bcl-2 homologues, which have become useful tools to investigate the mechanisms behind the control of the mitochondrial checkpoint of apoptosis. Concurrently, a number of viral inhibitors of innate immune signalling have been instrumenta...

journal_title：Microbes and infection

authors： Postigo A,Ferrer PE

更新日期：2009-11-01 00:00:00

abstract：:Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved...

journal_title：Microbes and infection

authors： Balloy V,Chignard M

更新日期：2009-10-01 00:00:00

abstract：:Sheep develop clinical diseases after 3-5 years after infection with Mycobacterium avium subsp. paratuberculosis (MAP). Clinical symptoms of paratuberculosis include persistent diarrhea and weight loss due to a chronic inflammation of the small intestine. Tissue alterations in the areas of the ileo-cecal junction are ...

journal_title：Microbes and infection

authors： Rossi G,Nigro G,Tattoli I,Vincenzetti S,Mariani P,Magi GE,Renzoni G,Taccini E,Bernardini ML

更新日期：2009-05-01 00:00:00

abstract：:The mechanisms and molecular effectors of pathogen recognition systems in diverse hosts are highly conserved. Both plant and animal recognition of pathogens relies on sensing of Pathogen-Associated Molecular Patterns (PAMPs) by Pattern Recognition Molecules (PRMs). To detect bacteria, these sensor molecules can recogn...

journal_title：Microbes and infection

authors： Charroux B,Rival T,Narbonne-Reveau K,Royet J

更新日期：2009-05-01 00:00:00

abstract：:This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sop...

journal_title：Microbes and infection

authors： Hajishengallis G

更新日期：2009-05-01 00:00:00

abstract：:Otitis media (OM) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection. This study has investigated how combinations of bacteria associated with nasal colonisation and the occurrence and absence of viral infection (Sendai virus) induce OM in a mouse nasal colonisation model. The...

journal_title：Microbes and infection

authors： Krishnamurthy A,McGrath J,Cripps AW,Kyd JM

更新日期：2009-04-01 00:00:00

abstract：:We previously reported prolonged HIV-1 transcriptional gene silencing by an RNA duplex targeting a sequence located within the NF-kappaB binding motif of the HIV-1 promoter in a susceptible HeLa cell line. Here we report extremely prolonged suppression of productive HIV-1 infection in a T-cell line (Molt-4) by a retro...

journal_title：Microbes and infection

authors： Yamagishi M,Ishida T,Miyake A,Cooper DA,Kelleher AD,Suzuki K,Watanabe T

更新日期：2009-04-01 00:00:00

abstract：:Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was a...

journal_title：Microbes and infection

authors： Ferreira CM,Pereira AT,Amaral FA,de Souza RS,Coelho FM,Souza DG,Negrão-Corrêa D,Teixeira MM

更新日期：2009-02-01 00:00:00

abstract：:Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis (Pb), a thermal dimorphic fungus. Its major antigen is a 43-kDa glycoprotein. Gp43 embodies different functions: it participates in evasion mechanisms during the installation of primary infection, stimulates granul...

journal_title：Microbes and infection

authors： Konno AY,Maricato JT,Konno FT,Mariano M,Lopes JD

更新日期：2009-01-01 00:00:00

abstract：:Most pandemic influenza virus strains undergo adaptation or reassortment before they acquire the ability to cause fatal infections in a new host species. The pathologic changes and tissue tropism during virus adaptation are not fully understood. Here we investigated pathologic changes and tissue tropism by serial lung...

journal_title：Microbes and infection

authors： Narasaraju T,Sim MK,Ng HH,Phoon MC,Shanker N,Lal SK,Chow VT

更新日期：2009-01-01 00:00:00

abstract：:The study established the virulence potential of multidrug-resistant Escherichia coli (MDREC) isolates from nosocomial infections in hospitalised dogs. The isolates were resistant to fluoroquinolones, belonged to two distinct clonal groups (CG1 and CG2) and contained a plasmid-mediated AmpC (CMY-7) beta-lactamase. CG1...

journal_title：Microbes and infection

authors： Sidjabat HE,Chin JJ,Chapman T,Wu K,Ulett GC,Ong CY,Schembri MA,Johnson JR,Trott DJ

更新日期：2009-01-01 00:00:00

abstract：:Mycoplasma arthritidis causes autoimmune arthritis in rodents. It produces a superantigen (MAM) that simultaneously activates antigen presenting cells and T cells inducing nitric oxide and cytokine release. Nitric oxide is a key inducer and regulator of the immune system activation. Here, we investigated nitric oxide ...

journal_title：Microbes and infection

authors： Shio MT,Olivier M,Jancar S,Ribeiro-Dias F

更新日期：2008-11-01 00:00:00

abstract：:The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the Gram-positive cell wall component peptidoglycan (PGN). Male mice (C57BL6/J or C3H/HeJ, 8-12 weeks of age) were given intraperitoneal injections of 1mg PGN on 2 consecutive days. The ...

journal_title：Microbes and infection

authors： Murphey ED,Sherwood ER

更新日期：2008-10-01 00:00:00

abstract：:We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...

journal_title：Microbes and infection

authors： de Melo TG,Meirelles Mde N,Pereira MC

更新日期：2008-10-01 00:00:00

abstract：:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigat...

journal_title：Microbes and infection

authors： Vielfort K,Sjölinder H,Roos S,Jonsson H,Aro H

更新日期：2008-10-01 00:00:00

abstract：:Infection with Brucella abortus induces a pro-inflammatory response that drives T cell responses toward a Th1 profile. The mechanism by which this bacterium triggers this response is unknown. Dendritic cells (DC) are crucial mediators at the host-pathogen interface and are potent Th1-inducing antigen-presenting cells....

journal_title：Microbes and infection

authors： Zwerdling A,Delpino MV,Barrionuevo P,Cassataro J,Pasquevich KA,García Samartino C,Fossati CA,Giambartolomei GH

更新日期：2008-10-01 00:00:00

abstract：:In the present study, we evaluated prophylactic prospective of liposome based DNA vaccine co-expressing Cu-Zn superoxide dismutase (SOD) along with interleukin-18 (IL-18) against experimental murine brucellosis. The immunization schedule involves liposome-mediated delivery of pVsod (encoding SOD of Brucella abortus) a...

journal_title：Microbes and infection

authors： Singha H,Mallick AI,Jana C,Isore DP,Goswami TK,Srivastava SK,Azevedo VA,Chaudhuri P,Owais M

更新日期：2008-08-01 00:00:00

abstract：:To obtain monkey-tropic viruses that are more closely related to HIV-1 than the original NL-DT5/NL-DT5R clones, we constructed six vif-chimeric and two site-specific vif-mutant viruses, and examined their growth ability. Different from NL-DT5/NL-DT5R, these viruses did not grow in monkey cells. We monitored the capabi...

journal_title：Microbes and infection

authors： Hatcho K,Kamada K,Yamashita T,Adachi A,Nomaguchi M

更新日期：2008-08-01 00:00:00

abstract：:Using a viral-induced immunopathology model, we showed that when CD4(+) T cells were allowed to undergo homeostatic expansion prior to ocular herpes simplex virus infection, mice developed more severe inflammatory lesions with the increased severity associated with enhanced effector function of ocular CD4(+) T cells, ...

journal_title：Microbes and infection

authors： Suvas S,Kim B,Rouse BT

更新日期：2008-08-01 00:00:00

abstract：:Over the last 10 years - in Microbes and Infection - the publications dealing with protozoan parasites were mainly providing insights on the pathogenic processes leading to the local or systemic damages in the mammals, these parasitic organisms exploit/subvert as hosts. As a result, many investigators introduced the o...

journal_title：Microbes and infection

authors： Milon G

更新日期：2008-07-01 00:00:00

abstract：:The PE and PPE family of proteins of Mycobacterium tuberculosis have been hypothesized to play important roles in the biology of the organism and some proteins have been shown to be involved in eliciting T-cell responses. Earlier, we had identified putative HLA class I binding epitopes of the PE and PPE proteins of My...

journal_title：Microbes and infection

authors： Chaitra MG,Shaila MS,Nayak R

更新日期：2008-07-01 00:00:00

abstract：:We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in...

journal_title：Microbes and infection

authors： Champion OL,Valdez Y,Thorson L,Guttman JA,Menendez A,Gaynor EC,Finlay BB

更新日期：2008-07-01 00:00:00

abstract：:Helicobacter hepaticus strain 3B1 (H. hepaticus) contains a genomic island of approximately 71 kb, HHGI1, with some of the common features shared among known bacterial pathogenicity islands. In this study, we characterized the pathogenic potential of HHGI1 by infecting B6.129-IL10 tm1Cgn (IL10-/-) mice with an isogeni...

journal_title：Microbes and infection

authors： Ge Z,Sterzenbach T,Whary MT,Rickman BH,Rogers AB,Shen Z,Taylor NS,Schauer DB,Josenhans C,Suerbaum S,Fox JG

更新日期：2008-06-01 00:00:00

abstract：:Francisella tularensis causes the zoonosis tularemia in humans, and inhaled F. tularensis ssp. novicida induces lethal murine tularemia. Transcription of virulence factors in F. novicida is regulated by macrophage growth locus A (mglA), a global regulator required for bacterial replication in macrophages in vitro. We ...

journal_title：Microbes and infection

authors： West TE,Pelletier MR,Majure MC,Lembo A,Hajjar AM,Skerrett SJ

更新日期：2008-06-01 00:00:00

abstract：:Drug-resistant tuberculosis (TB), including the more severe forms of multidrug- and extensively drug-resistant forms, is an increasing public health concern globally. In Sweden the majority of patients with TB are immigrants from countries with a high incidence of TB including the drug-resistant forms. In this study, ...

journal_title：Microbes and infection

authors： Ghebremichael S,Petersson R,Koivula T,Pennhag A,Romanus V,Berggren I,Petrini B,Hoffner S,Källenius G

更新日期：2008-05-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Microbes and infection

authors： Korten S,Badusche M,Büttner DW,Hoerauf A,Brattig N,Fleischer B

更新日期：2008-04-16 00:00:00

abstract：:Superinfection rates of human immunodeficiency virus type 1 (HIV-1) have increasingly been leading to more variation in HIV-1, as evidenced by the emergence of circulating recombinant forms (CRFs). We recently reported complementation in a persistently replication-defective subtype B-infected cell clone, L-2, by super...

journal_title：Microbes and infection

authors： Iwabu Y,Mizuta H,Kawase M,Kameoka M,Goto T,Ikuta K

更新日期：2008-04-01 00:00:00

abstract：:Translocation of normally non-pathogenic bacteria across the gut may drive inflammatory responses associated with sepsis and inflammatory bowel disease. Recent evidence suggests translocation may not be purely passive, but occurs via novel transcellular pathways activated in enterocytes by inflammatory and metabolic s...

journal_title：Microbes and infection

authors： Macutkiewicz C,Carlson G,Clark E,Dobrindt U,Roberts I,Warhurst G

更新日期：2008-04-01 00:00:00

abstract：:Population genetic structure and subdivision are key factors affecting the evolution of organisms. In this study, we analysed and compared the population genetic structure of the malaria parasite Plasmodium falciparum and its mosquito vector Anopheles gambiae over space and time in the Nianza Province, near Victoria L...

journal_title：Microbes and infection

authors： Prugnolle F,Durand P,Jacob K,Razakandrainibe F,Arnathau C,Villarreal D,Rousset F,de Meeûs T,Renaud F

更新日期：2008-03-01 00:00:00

abstract：:To survive macrophage killing is critical in the pathogenesis of viridians streptococci-induced infective endocarditis (IE). Streptococcus mutans, an opportunistic IE pathogen, generally does not survive well phagocytic killing in murine macrophage RAW 264.7 cells. A putative two-component system (TCS), ScnR/ScnK from...

journal_title：Microbes and infection

authors： Chen PM,Chen HC,Ho CT,Jung CJ,Lien HT,Chen JY,Chia JS

更新日期：2008-03-01 00:00:00

abstract：:It has been shown that persistent Staphylococcus aureus nasal carriage results in increased bacterial dispersal and a higher risk of infection compared to non-or-intermittent S. aureus carriage. Although many studies investigated S. aureus nasal carriage in HIV patients, none compared persistent carriage to non-persis...

journal_title：Microbes and infection

authors： Melles DC,Pauw E,van den Boogaard L,Boelens HA,Peters J,Peeters JK,Witsenboer H,van Leeuwen WB,Verbrugh HA,van Belkum A,Nouwen JL

更新日期：2008-02-01 00:00:00

abstract：:To increase knowledge of the pathogenic potential of the Burkholderia cepacia complex (BCC), we investigated the effects of reference strains of the nine BCC species on human bronchial epithelial cells in vitro. B. multivorans exhibited the highest rates of adherence to and internalization by host cells. Two out of th...

journal_title：Microbes and infection

authors： Moura JA,Cristina de Assis M,Ventura GC,Saliba AM,Gonzaga L Jr,Si-Tahar M,Marques Ede A,Plotkowski MC

更新日期：2008-01-01 00:00:00

abstract：:In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoH...

journal_title：Microbes and infection

authors： Machiels B,Gillet L,Nascimento Brito SD,Drion P,Delforge C,Nizet Y,Gianello P,Bona C,Costes B,Markine-Goriaynoff N,Vanderplasschen A

更新日期：2007-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs) and in the induction of immune responses. However, relatively little is known about their functions in innate/acquired responses to complex eukaryotic microorganisms, including helminth parasites. That Sch...

journal_title：Microbes and infection

authors： Vanhoutte F,Breuilh L,Fontaine J,Zouain CS,Mallevaey T,Vasseur V,Capron M,Goriely S,Faveeuw C,Ryffel B,Trottein F

更新日期：2007-11-01 00:00:00

abstract：:Effective vaccines against infectious diseases and biological warfare agents remain an urgent public health priority. Studies have characterized the differentiation of effector and memory T cells and identified a subset of T cells capable of conferring enhanced protective immunity against pathogen challenge. We hypoth...

journal_title：Microbes and infection

authors： Brice GT,Dobaño C,Sedegah M,Stefaniak M,Graber NL,Campo JJ,Carucci DJ,Doolan DL

更新日期：2007-10-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) infects macrophages and causes demyelinating disease (DD) in certain mouse strains. IL-23 p19/p40 and IFN-beta, which are both expressed by macrophages in response to TMEV, could contribute to or prevent DD. Because TMEV may induce macrophages' cytokines through TLR3 and...

journal_title：Microbes and infection

authors： Al-Salleeh F,Petro TM

更新日期：2007-09-01 00:00:00

abstract：:T cells are thought to play a critical role in cerebral malaria pathogenesis. However, available evidences are restricted to rodent models in which V beta specific T cell expansion has been associated with neurological syndrome suggesting involvement of superantigens or dominant antigens. Using flow cytometry, we stud...

journal_title：Microbes and infection

authors： Loizon S,Boeuf P,Tetteh JK,Goka B,Obeng-Adjei G,Kurtzhals JA,Rogier C,Akanmori BD,Mercereau-Puijalon O,Hviid L,Behr C

更新日期：2007-09-01 00:00:00

abstract：:Syphilis, a sexually transmitted infection caused by the spirochetal bacterium Treponema pallidum, remains a global public health problem. T. pallidum is believed to be an extracellular pathogen and, as such, the identification of T. pallidum outer membrane proteins that could serve as targets for opsonic or bacterici...

journal_title：Microbes and infection

authors： Tomson FL,Conley PG,Norgard MV,Hagman KE

更新日期：2007-09-01 00:00:00

abstract：:West Nile virus is now distributed throughout many temperate, subtropical and tropical areas: vaccines need to be developed that are affordable for developed and developing countries. Here, we constructed and evaluated a DNA vaccine expressing the premembrane and envelope proteins of West Nile virus (pcWNME). Mice imm...

journal_title：Microbes and infection

authors： Ishikawa T,Takasaki T,Kurane I,Nukuzuma S,Kondo T,Konishi E

更新日期：2007-07-01 00:00:00